Helical Structure of Recombinant Melittin. Biomacromolecules , 17 8 , Langmuir , 34 24 , Trifluoroethanol is a key precursor for the inhaled anaesthetic isoflurane , listed on the World Health Organization 's List of Essential Medicines.
Roberto D. The helix-stabilizing effect by reducing the non-polar surface area has been stressed in several previous studies Padmanabhan and Baldwin, , and references therein; Zhang et al. Pulikallu Sashi, U. Journal of the American Chemical Society , 49 , Lopez-Silva, David G. Avijita Jain, Garry W.
The effect of TFE at two different temperatures is shown in Figure 1a and b. It also serves as a source of the trifluoromethyl group for various chemical reactions Still-Gennari modification of HWE reaction. The Journal of Organic Chemistry , 79 17 , Chiluwal, Diane E. Peters, Danielle Whicher, James L. The details of the laser-induced temperature jump T-jump IR setup have been described elsewhere.
Ulrich, and Murat Kazanci. Pulikallu Sashi, U. Biochemistry , 49 27 , Pengcheng Zhang, Andrew G. Hileman,, Heather K.
At least for tert-butyl alcohol Iwasaki and Fujiyama, and hexafluoropropanol Kuprin et al. It competitively inhibits alcohol dehydrogenase for example. Each group is hydrophobically hydrated with water molecules forming polygons. This model also provides an explanation for TFE-induced transitions between secondary structures, in which the TFE clusters may redirect non-local to local interactions. Industrially trifluoroethanol is employed as a solvent for nylon as well as in applications of the pharmaceutical field.
The effect of TFE at two different temperatures is shown in Figure 1a and b. IDPs are ideal candidates for this study, because they lack appreciable tertiary structure when isolated in buffer, simplifying our interpretations. The Journal of Organic Chemistry , 79 17 , Biomacromolecules , 8 2 , Hammond, and, Kevin C. Again, TFE disrupts tertiary interactions in proteins [by weakening non-polar interactions Gast et al.
This model accounts for the various effects TFE on hydrophobic groups in peptides and proteins and may provide an explanation for the phenomenon of cold denaturation.
Due to the lack of baselines in these CD T-melts, as well as the changing nature of the T-melts themselves as a function of TFE percentage, no quantitative analysis was performed to extract additional information from this data. Biochemistry , 49 27 , Specifically, we studied the phosphorylated kinase inducible domain pKID peptide 31 and the late embryogenesis abundant LEA peptide. Indeed, Hamada et al.